The victory in Leipzig crowns a spectacular two years for the Eagles under Oliver Glasner. The Austrian guided Palace to a first-ever major trophy when they defeated Manchester City in the FA Cup final last season, and have now followed that up with victory on the continent.
In between, Palace also got their hands on the Community Shield, when they overcame Liverpool on penalties.
Glasner is set to leave the club at the end of the season at the expiration of his contract, following reports of discontent and frustration in the middle of the campaign over Palace's transfer business.
Palace were initially meant to take part in Europe's second-tier competition, the Europa League. However, they were demoted to the Conference League following breached regulations because former co-owner John Textor held shares in Palace and Lyon, with the latter also qualifying for the same competition.
They will now participate in the Europa League in 2026/27 as a result of their Conference League victory.
Palace finished outside the top eight during the league phase and had to play an extra game in a knockout play-off. En route to the final, they saw off Zrinjski Mostar, AEK Larnaca, Fiorentina and Shakhtar Donetsk.
Palace star Ismaila Sarr is the competition's top scorer with nine goals in 13 games, while no other teammate has scored more than twice.
Daichi Kamada has four assists, the second-highest in the competition.