The Western Australia capital will also host the Wallabies-Italy test at HBF Park (Perth Rectangular Stadium) on July 18, part of the inaugural Nations Championship matches.
Melbourne, however, has missed out on hosting a test in 2026, continuing its run of being sidelined by rugby officials.
The nation's second largest city was overlooked as a host for knockout matches in next year's Rugby World Cup in Australia, barring one round-of-16 clash.
While outgoing coach Joe Schmidt will be in charge for the Wallabies' Nations Championship tests against Ireland, France and Italy in July, Queensland Reds boss Les Kiss takes the reins against Eddie Jones's Japan in the following month.
The Wallabies will travel to Osaka to play Japan on August 8 before a home clash against the Brave Blossoms in Townsville on August 15.
The Bledisloe Cup, Australia's annual series against New Zealand, kicks off on October 10 at Auckland's Eden Park, where the Wallabies have not beaten the hosts since 1986.
The teams meet in Sydney a week later for the second and final Bledisloe Cup test.
The All Blacks have held the Bledisloe Cup uninterrupted since 2003.
Venues for Australia's back-to-back away tests against Argentina on August 29-September 5 have yet to be confirmed.
Wallabies 2026 home games:
Saturday 4 July v Ireland (Allianz Stadium, Sydney)
Saturday 11 July v France (Suncorp Stadium, Brisbane)
Saturday 18 July v Italy (HBF Park, Perth)
Saturday 15 August v Japan (Queensland Country Bank Stadium, Townsville)
Sunday 27 September v South Africa (Optus Stadium, Perth)
Saturday 17 October v New Zealand (Accor Stadium, Sydney)
Two mid-year home games v Argentina have venues yet to be determined.