Argentina had to do without many of their Europe-based players in their last international against Australia in Mendoza on September 5, which ended in a 28-28 stalemate.
Coach Felipe Contepomi has injury issues this time round but has been able to pick a much stronger side with the backline all changed and only Pablo Matera and Boris Wenger retained in the forward pack.
Julian Montoya returns to captain the team as Argentina look for a first win over Ireland in Dublin, having lost 11 times previously to their hosts.
Santiago Chocobares has been included at centre despite concerns after he suffered a head knock playing in the French league last month.
The notable absentees for the Pumas are Santiago Carreras, who suffered a serious knee injury playing for Bath in England last month, and prop Thomas Gallo, who had surgery on his left wrist hurt while playing club rugby in France.
Nations Championship 2026
The inaugural Nations Championship will see six northern hemisphere and six southern hemisphere nations battle it out across six rounds in the July and November international windows before assembling in Twickenham for one unforgettable finals weekend on November 27-29.
Nations Championship fixtures | Nations Championship previews | Nations Championship standings | Nations Championship news | Everything you need to know about the Nations Championship | Where to watch the Nations Championship
Argentina team:
Starters: 15-Juan Cruz Mallia, 14-Bautista Delguy, 13-Justo Piccardo, 12-Santiago Chocobares, 11-Mateo Carreras, 10-Tomas Albornoz, 9-Gonzalo Garcia, 8-Pablo Matera, 7-Marcos Kremer, 6-Juan Martin Gonzalez, 5-Pedro Rubiolo, 4-Guido Petti, 3-Francisco Moreno, 2-Julian Montoya (captain), 1-Boris Wenger.
Replacements: 16-Leonel Oviedo, 17-Mayco Vivas, 18-Joel Sclavi, 19-Efraín Elias, 20-Juan Martin Scelzo, 21-Simon Benitez Cruz, 22-Geronimo Prisciantelli, 23-Lucio Cinti.
Ireland team:
Starters: 15-Hugo Keenan, 14-Rob Baloucoune, 13-Robbie Henshaw, 12-Stuart McCloskey, 11-Mack Hansen, 10-Sam Prendergast, 9-Craig Casey, 8-Sean Jansen, 7-Nick Timoney, 6-Ryan Baird, 5-Tadhg Beirne, 4-Joe McCarthy, 3-Tadhg Furlong, 2-Dan Sheehan (captain), 1-Andrew Porter.
Replacements: 16-Ronan Kelleher, 17-Tom O'Toole, 18-Sam Illo, 19-James Ryan, 20-Josh van der Flier, 21-Jamison Gibson-Park, 22-Ciaran Frawley, 23-Bundee Aki.