Chiefs have been handed a bye in the first preliminary round of the continental competition, but will then face a tough tie for a place in the group stages against either Red Arrows or FC Rouge.
The Malagasy side may be the more favourable opponent, but neither will be an easy prospect as Chiefs look to improve on their group-stage finish last season.
Meanwhile, Durban City take on Rukinzo FC from Burundi in the first preliminary round. Should they advance, they will meet the winner of the tie between AS Port Louis of Mauritius and Jwaneng Galaxy of Botswana for a place in the group stages.
First Preliminary Round
Mogadishu CC (Somalia) vs Kitara FC (Uganda)
ZED FC (Egypt) vs ASAS Djibouti Télécom (Djibouti)
Al Hilal Alsahil (Sudan) vs Welwalo Adigrat (Ethiopia)
KMKM SC (Zanzibar) vs Al Ahly Tripoli (Libya)
Al Ahli Madani (Sudan) vs Tusker FC (Kenya)
Al-Ghazala SC Wau (South Sudan) vs Singida Black Stars (Tanzania)
The Panthers FC (Equatorial Guinea) vs ASPAC FC (Benin)
AS PSI (Chad) vs CO Korhogo (Côte d’Ivoire)
AS Douanes (Mauritania) vs Hafia FC (Guinea)
El Kanemi Warriors (Nigeria) vs UDIB (Guinea-Bissau)
AF Amadou Diallo (Côte d’Ivoire) vs East End Lions FC (Sierra Leone)
Shooting Stars (Nigeria) vs CS Sfaxien (Tunisia)
ES Zarzis (Tunisia) vs Diambars FC (Senegal)
Vitesse FC (Burkina Faso) vs AS Real de Bamako (Mali)
FC Diarra (Mali) vs Nations FC (Ghana)
AS ZAM (Niger) vs ASKO de Kara (Togo)
UNAM (Namibia) vs Kabuscorp de Palanca (Angola)
Red Arrows FC (Zambia) vs FC Rouge (Madagascar)
Durban City FC (South Africa) vs Rukinzo FC (Burundi)
AS Port Louis 2000 (Mauritius) vs Jwaneng Galaxy (Botswana)
Panthère Sportive (Cameroon) vs Rayon Sports FC (Rwanda)
Atomic Ngomé (Comoros) vs Associação Black Bulls (Mozambique)
DC Virunga (DR Congo) vs PTL Bazar Brothers (Seychelles)
Green Mamba (Eswatini) vs CD Primeiro de Agosto (Angola)
Second Preliminary Round
Mogadishu CC or Kitara FC vs Al Ahly FC (Egypt)
ZED FC or ASAS Djibouti Télécom vs Azam FC (Tanzania)
Al Hilal Alsahil or Welwalo Adigrat vs KMKM SC (Zanzibar) or Al Ahly Tripoli (Libya)
Al Ahli Madani or Tusker FC vs Al-Ghazala SC Wau or Singida Black Stars
The Panthers FC or ASPAC FC vs USM Alger (Algeria)
AS PSI or CO Korhogo vs AS FAR (Morocco)
AS Douanes or Hafia FC vs CR Belouizdad (Algeria)
El Kanemi Warriors or UDIB vs Raja Casablanca (Morocco)
AF Amadou Diallo or East End Lions FC vs Shooting Stars or CS Sfaxien
ES Zarzis or Diambars FC vs Vitesse FC or AS Real de Bamako
FC Diarra or Nations FC vs AS ZAM or ASKO de Kara
UNAM or Kabuscorp de Palanca vs AS Maniema Union (DR Congo)
Red Arrows FC or FC Rouge vs Kaizer Chiefs FC (South Africa)
Durban City FC or Rukinzo FC vs AS Port Louis 2000 or Jwaneng Galaxy FC
Panthère Sportive or Rayon Sports FC vs Atomic Ngomé or Associação Black Bulls
DC Virunga or PTL Bazar Brothers vs Green Mamba or CD Primeiro de Agosto